This blog challenges the widely accepted belief that cholesterol is the primary cause of heart disease and questions the effectiveness of statins, a $10 billion-a-year industry. While statins successfully lower cholesterol levels, the blog argues that they may not significantly reduce the risk of heart attacks and strokes. It highlights the difference between good and bad cholesterol, the potential harm from polyunsaturated oils, and the misleading presentation of statin benefits through Relative Risk Reduction (RRR). The blog also discusses the side-effects of statins, including muscle pain and fatigue, urging individuals to make informed decisions about their health.
Statins are big business. The miracle drug that helps prevent heart attacks and strokes is estimated to be a $10B a-year industry. Statins are drugs that are reputed to lower cholesterol, but do they work? If you measure their efficacy in terms of lowering levels of cholesterol in the body, then yes they do. But if we look at whether they reduce the risk of heart attacks and strokes then that’s a different story.
The Demonisation of Cholesterol
Cholesterol has been demonised as the major contributing factor in causing heart disease. Here’s the theory behind this:
- Most heart attacks are caused by blockage due to the build up of plaque in the coronary arteries that supply the heart.
- Cholesterol is a major component of that plaque.
- The plaque build-up eventually cuts off the blood supply to certain areas of the heart, causing oxygen deficiency, pain (angina) and ultimately a heart attack.
It stands to reason that cholesterol (as it is always present in arterial plaque), must be a major concern and therefore reducing it is a good idea.
Good and Bad Cholesterol
You may have heard about good and bad cholesterol. High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL). HDL is the good stuff because it picks up excess cholesterol and takes it back to the liver, whereas LDL is the stuff that carries cholesterol to the arterial blockage. HDL and LDL are not actually cholesterol but proteins that act as transport mechanisms for cholesterol to and from the liver.
One of the best analogies I saw on this subject was this:
Blaming cholesterol for causing heart attacks is like blaming firemen for causing fires, as they are always there at the scene.
The cholesterol is actually there due to the body’s intelligent response to damaged tissue, it’s there to heal, not to harm.
In fact, cholesterol is vital to the process of building healthy cells, for hormone production and for producing cortisol, which is the body’s own anti-inflammatory agent. It’s the precursor to the production of vitamin D and it’s a powerful antioxidant that protects against cancer and ageing.
Cholesterol is Vital to the Body
Given that cholesterol is so vital to the body, why would we want to suppress its production? Maybe the body is producing too much of it? Well, that supposes that your body is not intelligent and doesn’t know what it’s doing. The production of cholesterol is the body’s natural response to dealing with inflammation. In other words, it’s trying to heal tissue damage.
The Real Cause of Atherosclerosis?
What causes the narrowing of the arteries from plaque – atherosclerosis? If the blockage is caused by cholesterol, then why don’t our veins and capillaries get clogged up too? Atherosclerosis only occurs in arteries because the muscular layer in arterial walls get damaged by free radicals, sourced from the polyunsaturated oils in our diet.
Polyunsaturated oils are vegetable oils we were told to switch to because they are “healthier” than saturated fats. The higher ratio of Omega 6 to Omega 3 that is in most vegetable oils has an inflammatory effect on the body, unlike fish oil which has a higher level of Omega 3.
It is the increased consumption of these oils that is causing the free radical damage to the arterial walls. We need to be reducing the stuff that causes the damage, not the stuff that is there to repair it. When we do this, our bodies will get the chance to recover.
How do Statins Reduce Cholesterol in the Body?
So, how do Statins reduce cholesterol in the body? Cholesterol is produced by the liver, which produces so many chemicals, enzymes and nutrients in a vastly complex branch of reactions. Imagine that the liver is a tree where the end of each twig is a vital compound for the body, such as cholesterol.
Statins don’t prune that single twig, they actually cut further into the branch, reducing other vital “twigs”. One such twig is Coenzyme Q10 (COQ10). COQ10 is used for energy production by every cell in your body. Without it, your muscles will weaken, including the heart which is a major muscle. Another “twig” is Vitamin K2, which protects arteries from calcification and removes calcium from where it shouldn’t be in soft tissues.
Relative Risk v/s Absolute Risk
Statins became such big business, partly down to the cholesterol myth (blaming the fire fighters). And also partly due to how the risk is presented. When discussing risk reduction of disease due to medication or the risk of unwanted side-effects from that medication, it is important to understand the difference between Relative Risk Reduction (RRR) and Absolute Risk Reduction (ARR).
Here’s an example to illustrate the difference. One study showed that for high-risk patients with Type 2 Diabetes, taking 10mg of Atorvastatin every day for 4 years reduced the risk of that patient experiencing a stroke by 48%.
That’s an impressive statistic and would convince many people in a 10 minute consultation with their GP. However, the real figures behind it tells a different story. The numbers show the risk of suffering a stroke is reduced from 28 in 1000 people down to 15 in 1000. In other words, by taking the drug, 13 people in 1000 were prevented from having a stroke. In Absolute Risk Reduction terms that is only 1.3%. Compare that to the 48% quoted in RRR terms! Another way to look at it is that most people do not benefit.
Playing with the Numbers
There is a tendency to report the benefits of a drug in terms of Relative Risk Reduction, whilst harmful side-effects are reported in absolute terms. For example, if treatment A, reduces the risk of developing disease from 10 to 7 in 1000 people, but increases the risk of harmful effect B from 7 to 10 in 1000, medical journal articles tend to report the benefit as a 30% risk reduction. However, the harmful side affect has an increase of 3 in 1000 or 0.3%.
A study showed that one third of the articles in medical journals published in Lancet, BMJ (British Medical Journal) and JAMA (Journal of the American Medical Association), between 2004 and 2006 did the above.
Statin Side-Effects
What are the side effect risks of statins? One popular Statin called ‘Lipitor’, has a list of side-effects that includes: headache, joint pain, mild muscle pain, constipation, diarrhoea, stomach pain or indigestion, mild nausea, mild skin rash, sleep problems, jaundice, dark urine, confusion, muscle wasting, liver and kidney problems.
Take a look here and see for yourself. The effects are such that 58% of patients stop taking them within a year, mostly because they experience muscle pain and fatigue.
I remember discussing this with one of my clients who was taking Statins. I sent her some links to videos which explained what I’ve outlined in this blog. Several months later she told me that she had decided to stop taking Statins on the basis of the evidence outlined in those videos. She explained that after 3 months (which is how long it takes to start to recover from Statin side-effects) she realised that she could walk downstairs without feeling like an old woman.
When she next saw her GP, it was with much trepidation. She told him that she had stopped taking her Statin prescription. He tested her cholesterol levels and found that they were within what was considered a healthy range; so he removed the Statins from her repeat prescriptions. I’m convinced that the cholesterol reduction was due to her changes in diet by virtually eliminating sugar and grain-based vegetable oils.
She then reported that her husband, who was also taking Statins and suffering from muscle pains, decided to stop taking them, to see what would happen. Sure enough the muscle aches went away. He then resumed the Statins and those aches returned.
Be Fully Informed
As a Kinesiologist I am a complementary health practitioner and as such I cannot, and would not, advise anyone to stop taking any prescribed drugs. But, I think everyone should be completely aware of the facts so that they can make a fully informed decision before starting treatment with drugs. That includes, understanding the real benefits in terms of disease risk reduction and side-effects of any medication.
When you next have a discussion with your GP about whether a drug, such as Statins, would be beneficial, make sure that they can explain these risks to you in absolute terms. Ultimately it is your decision about what medical treatment to receive and whether you believe the benefits really outweigh the risk.
Some Informative Videos to Watch
- Statins: Trivial Benefits at a great cost – Dr. Eric Berg
- Profit over population health – Dr. Aseem Malhotra
- Cholesterol – Dr. John Bergman
This blog was written by guest blogger Simon Lawton.
Simon is a TASK trained Systematic Kinesiologist based in Epsom, Surrey, UK. He is passionate about Kinesiology and loves the way that it directly communicates with the body to identify and rectify the root cause of health issues allowing it to return to its natural state of health.